Sodium benzoate has the chemical formula nac 7 h 5 o 2. Sodium benzoate supplier manufacturer e211 buy sodium. Sinofi is a reliable e211 sodium benzoate supplier and manufacturer of in china. Sodium benzoate nab upregulates bdnf and nt3 in primary human neurons. Sodium benzoate cas 532321 emprove essential ph eur,bp,nf,fcc,e 211 find msds. Sodium benzoate usp pharmacopoeia reference standards. Sodium benzoate is usually given three or four times a day. Sodium benzoate usp, sodium benzoate usp supplier, sodium benzoate usp distributor, cas 532321, sodium benzoate usp manufacturer, sodium benzoate usp wholesale skip to main content covid19 status. Dailymed docusate sodium, sennosides tablet, film coated.
One g dissolves in 2 ml of water, in 75 ml of alcohol, and in 50 ml of 90% alcohol. Final report on the safety assessment of benzyl alcohol. List of united states pharmacopoeia usp analytical reference standards of sodium benzoate and related impurities. Effect of sodium benzoate preservative on micronucleus. Sodium benzoate is food preservative that inhibits microbial growth. It is currently approved for use in canada, the usa, the eu, austalia, and new zealand. Caffeine and sodium benzoate injection, usp is a clear, sterile, nonpyrogenic, solution of caffeine alkaloid. Requirements identification it gives positive tests for sodium, page 517, and for benzoate, page 516. Thats why, at 1800shavedice, we carry sodium benzoate preservative in 1gallon jugs. Safety assessment of benzyl alcohol, benzoic acid and its.
Benzenecarboxylic acid sodium salt, benzoic acidsodium salt, phenylformic acid sodium salt. When used with citric acid, just one jug of our sodium. Usp is not responsible for the accuracy or completeness of the information furnished. Nov 05, 2018 sodium benzoate has a chemical formula of c7h5nao2. Sodium benzoate for urea cycle disorders medicines for. Probenztm sp powder sodium benzoate, food grade, kosher. It can be produced by reacting sodium hydroxide with benzoic acid. Sodium benzoate is a substance which has the chemical formula c 6 h 5 coona.
As a food preservative, sodium benzoate nac 6 h 5 co 2 seems to be the most commonly used salt of benzoic acid. For the most uptodate version of cfr title 21, go to the electronic code of federal regulations ecfr. Find products that are predicted to be compatible with sodium benzoate usp. Sodium benzoate is the sodium salt of benzoic acid used as a preservative, also in a wide range of cosmetic product types. Assay transfer about 600 mg of sodium benzoate, accurately weighed, to a 250ml beaker. We can supply high quality sodium benzoate for sale. Rapid highperformance liquid chromatography method for the. The information on this page is current as of april 1 2019. Probenztm sp powder sodium benzoate, food grade, kosher version 1. I2 acetyalumi combined index to usp 41 and nf 36 acetyltriethyl citrate, 5183 povidoneiodine topical, 3392 alkaline nacetyltyrosine, 4418 terbutaline sulfate inhalation, 3986 borate buffer, 5676 nacetylltyrosine ethyl ester, 5665 thimerosal topical, 4056 cupric citrate ts, 5750 acid tolnaftate topical, 45 cupric citrate ts 2, 5750 acrylic, 5665 triamcinolone acetonide topical, 4186.
Benzoic acid is an aromatic acid used in a wide variety of cosmetics as a ph adjuster and preservative. Sodium benzoate has also been approved by fda for use as an antimycotic when migrating from foodpackaging material 21 cfr 181. Usp reference standards h11i usp saccharin sodium rs. It is a widely used food preservative, with an e number of e211. When used with citric acid, just one jug of our sodium benzoate can preserve 128 gallons of simple syrup. The joint faowho committee on food additives jecfa has allocated an acceptable daily intake adi of sodium benzoate and potassium benzoate at 05 mgkg body weight. Rapid highperformance liquid chromatography method for. These preservatives are commonly used as antimicrobial substances in many kinds of foods, such as, marinated fish, fruitbased fillings, jam, salad cream, soft drinks, and beer. Learn more about hansen solubility parameters hsp and their use in. Probenztm sp powder sodium benzoate, food grade, kosher product code. If adverse effects associated with increased sodium concentrations occur, the drug should be discontinued, the patient promptly evaluated, and. We offer publicly available, official documentary standards for pharmaceutical ingredients in the uspnf that link directly with a primary reference standard. It is used most commonly in acidic foods such as salad dressings vinegar, carbonated drinks carbonic acid, jams and fruit juices citric acid, pickles vinegar, and condiments. Sodium benzoate fccusp grade 19008 sodium bicarbonate 19010.
Sodium benzoate msds material safety data sheet or sds, coa and coq, dossiers, brochures and. Upregulation of neurotrophic factors by cinnamon and its. Benzyl alcohol, benzoic acid and its salts ie, sodium, calcium, magnesium, and potassium benzoate, and benzyl benzoate are reported to function as fragrance ingredients, pesticides, ph adjusters, preservatives, solvents, andor viscosity decreasing agents in cosmetic products. Download cosmetics and personal care chemicals brochure download glycerine, phosporic acid, sorbitol, and propylene glycol brochures download glycolic acid, dmdm, sles, ddbsa brochures download potassium sorbate, sodium benzoate, sodium gluconate, and potassium bicarbonate brochures. Apr 01, 2019 the information on this page is current as of april 1 2019. Sodium benzoate, powder, nf is a tablet and capsule lubricant used in the pharmaceutical formulations. Receive notifications based on your needs and usage by downloading the usp reference standards app today. The evaluation of the genotoxicity of two food preservatives. Sodium benzoate is effective preservation for jam, jellies especially when packed in large wooden containers for shipment to bakeries or other large scale users. Sodium benzoate is an antimicrobial preservative and flavoring agent used in the food industry and a tablet and capsule lubricant used in the pharmaceutical manufacturing industry.
It has a role as an antimicrobial food preservative, a drug allergen, an ec 1. Rapid highperformance liquid chromatography method for the analysis of sodium benzoate and potassium sorbate in foods article in journal of chromatography a 88312. Click on any product description to access the sds and the usp certificate, if available. Sodium benzoate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. Wintersun chemical has been a premier chemical ingredients supplier distributing high quality cosmetics and personal care chemicals to businesses. Sodium benzoate is created by adding benzoic acid to a hot concentrated solution of sodium carbonate until effervescence ceases. It is bacteriostatic and fungistatic under acidic conditions. Previous stage 6 posting in pf 36 5, 2010 previous stage 6 posting in pf 30 4, 2004 should you have any questions about the methylparaben monograph, please contact dr. It responds to the tests for sodium and for benzoate. Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 22 2016. Usp provides safety data sheets sds for all reference standards and usp certificates for some reference standards. Sodium benzoate united states pharmacopeia usp reference. Benzyl alcohol is metabolized to benzoic acid, which reacts with glycine and excreted as hippuric acid in the human body. Spectrum chemical nf products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities.
Parchem is open and ready to supply materials 18002823982 read more. Pdf a comparison between uv spectrophotometer and high. Sodium benzoate c6h5coona or nac6h5coo or c7h5o2na or. Download product safety card request more information about this product request a sample.
Perform a blank determination, and make any necessary correction. Chapter 16 antimicrobial preservatives 209 lwbk127c16203215. Add 100 ml of glacial acetic acid, stir until the assay specimen is completely dissolved, add 2 drops of crystal violet ts, and titrate with 0. Usp certificates and valid use dates for previous lots. Docusate sodium usp bp 85% with sodium benzoate by. It is also used as a preservative in medicines and cosmetics. Cosmetics and personal care chemicals wintersun chemical. Sodium benzoate is a food preservative and protects against yeasts, moulds, and certain types of bacteria. Labelingwhere the quantity of saccharin sodium is indicated in the labeling of any preparation containing saccharin sodium, this shall be expressed in terms of saccharin c 7 h 5 no 3 s. Sodium benzoate usp supplier distributor cas 532321. A practical determination of these hsp values would provide higher certainty. The effects of sodium benzoate preservative on micronucleus induction, chromosome break, and ala40thr superoxide dismutase gene mutation in lymphocytes were studied.
Although there is growing knowledge about the role of neurotrophins in the health and survival of neurons, stem cells as well as oligodendrocytes, little is known about the drugs and associated molecular mechanisms that upregulate neurotrophins. Commentary first supplement to usp 36nf 31 posted february 1, 20. Sodium 1,4bis2ethylhexyloxy1,4dioxo2butanesulfonate doss dss dioctyl sodium sulphosuccinate dioctyl sodium sulfosuccinate natridocusas aerosol ot aot 1,4bis2ethylhexyl sodium sulfosuccinate 2ethylhexyl sulfosuccinate. Sodium benzoate bp usp nf fcc ip food grade suppliers. It is the sodium salt of benzoic acid and exists in this form when dissolved in water. The solution is then evaporated, cooled and allowed to crystallize or evaporate to dryness, and then granulated. Sodium benzoate is synthesized by combining benzoic acid with sodium hydroxide. Sodium benzoate cas 532321 emprove essential ph eur,bp,nf,fcc,e 211 find msds or sds, a coa, data sheets and more information. Please call usp customer service at 18002278772 or 3018810666 to order. Caffeine and sodium benzoate injection fda prescribing. Sodium benzoate added to increase the solubility of caffeine 125 mg.
Learn more about hansen solubility parameters hsp and their use in predictive formulation. Sodium 1,4bis2ethylhexyloxy1,4dioxo2butanesulfonate doss dss dioctyl sodium sulphosuccinate dioctyl sodium sulfosuccinate natridocusas aerosol ot aot 1,4bis2ethylhexyl sodium sulfosuccinate 2ethylhexyl. Sodium phenylacetate and sodium benzoate injection should be used with caution, if at all, in patients with congestive heart failure chf, severe renal impairment, or sodium retention with edema. Sodium benzoate preservative is very soluble in water while e211 food additive is sparingly soluble in alcohol. Sodium benzoate and pb induced a significant increase in the frequency of cas and cacell in all concentrations and treatment periods as compared to the negative control. These increases in the frequency of cas and cacell were dosedependent, both in the 24 and 48h treatments for sb, r 0. Sodium benzoate nffcc sodium benzoate is a preservative. For information on pricing, availability and packaging of custom sizes, please contact stable isotopes customer service. I4 ammonartic combined index to usp 41 and nf 36 ammonium continued analytical procedures for recombinant citrate phosphate dextrose adenine reineckate ts, 5751 therapeutic monoclonal antibodies. This study underlines the importance of cinnamon, a widelyused food spice and flavoring material, and its metabolite sodium benzoate nab, a widelyused food preservative and a fdaapproved drug against urea cycle disorders in humans, in increasing the levels of neurotrophic factors e. Sodium benzoate extends the shelf life of your syrup so that you dont have to throw away unsold portions. If it makes you feel better, im a chemist, and i can tell you that sodium benzoate is a safe chemical for humans. It has an ld50 with rats of 4100 mgkg, meaning you would have to eat 1.